Androgenic alopecia \u2013 or male pattern baldness \u2013 is the most common form of hair loss and will effect around two-thirds of men and one-third of women during their lifetime.<\/p>\n
Regeneration response<\/h3>\n
Our recent study<\/a>, published in Cell, and completed on a mouse model, is unique because it not only studies the regeneration of a single hair follicle, but focuses on the regrowth of several follicles that had previously been effected by alopecia.<\/p>\n We demonstrated that plucking a few properly arranged hairs can trigger regeneration of hair follicles stem cells in up to five times more neighbouring, un-plucked surrounding hairs.<\/p>\n It is not surprising that follicle stem cell injury \u2013 caused by plucking \u2013 can cause a regeneration response. But, generally the stimulation of one stem cell through injury is only thought to cause regeneration in that stem cell alone.<\/p>\n Triggering the regeneration of a whole head of hair in this way would be highly inefficient. But can the regeneration response of several stem cells be triggered by stimulating only a few key cells or signals?<\/p>\n Recently, we accidentally discovered that regeneration could occur through a collective decision-making process. By plucking the correct number of hairs with a proper arrangement, up to five times more neighbouring, unplucked resting hairs were activated to regrow. But if the number of plucked hairs was below a threshold, no hairs regenerated.<\/p>\n Collective-decision time. Cheng-Ming Chuong, CC BY<\/p><\/div>\n This type of regeneration is an all-or-nothing process which is dependent on the signals produced by a fraction of hairs being plucked, and is an example of the process known as \u201cquorum sensing\u201d<\/a>.<\/p>\n Quorum sensing can be thought of as a decision-making process which is dependant on certain criteria being met within a population. Signalling molecules are released by each stimulated component of the population, the more components that are stimulated the more signal molecules are released.<\/p>\n As the elements in the system are able sense the number of signal molecules released by the population as a whole, they can also sense the degree of stimulation. When a certain threshold of stimulation is reached, a collective response from the components in the system will follow.<\/p>\n The process of quorum sensing has been used to describe bacteria cell-to-cell communication, where the expression of certain genes is coordinated between many bacteria in response to environmental factors such as an increase in the presence of bacterial toxins. Quorum sensing has also been used successfully to explain the behaviour of social insects<\/a> such as ants and honey bees for their collective decision-making.<\/p>\n But in reality, how does the population of hair follicles \u201ccast and count its vote\u201d in quorum sensing?.<\/p>\n First, there is a stimulus \u2013 such as hair plucking, which stimulates follicle stem cells \u2013 to some, but not all, hair follicles. Second, the plucked hair sends out a signal to surrounding cells. Third, the group of cells gauges the intensity of signal from its surroundings.<\/p>\n Finally, a local decision is made within the population in an all-or-nothing fashion: if enough hairs have been plucked, mass hair regrowth will occur, but if not, there will be no response at all.<\/p>\n In the most simple cases of quorum sensing, the signal molecule spreads by diffusion from the secreting cell. But it was found that the signals being released by plucked hair follicles were travelling further than could be achieved by simple diffusion, suggesting that a something more complicated was involved.<\/p>\n Molecular and genetic analysis revealed that the signals were transmitted through a two-step immune response, triggered by the plucking of the hair follicle. First injured hair follicle stem cells will release a small signal molecule, this recruits a specific cell type involved in the immune response called a macrophage<\/a>.<\/p>\n This then secretes a signal molecule involved in the immune response called a cytokine<\/a>, which acts directly on surrounding hair follicle cells by stimulating various cellular regeneration signal pathways.<\/p>\n This work shows that a quorum-sensing system can sense cell injury and use immune response to quantify how much damage has occurred.<\/p>\n The stem cell population then disregards the stimulus if the minimum number of hairs has not been plucked, or responds to it with a full-scale regenerative response in many hair follicles when a threshold is reached.<\/p>\n This finding also is important in the field of regeneration medicine as a whole. We believe that the quorum-sensing behaviour principle is likely to be present in the regeneration of tissue and organs beyond the skin.<\/p>\n Using such efficient regenerative strategies opens a new window in treating hair loss as well as many other degenerative disorders.<\/p>\n This article was co-written with Chih-Chiang Chen from the Taipei Veterans General Hospital<\/em><\/strong><\/p>\n By Cheng-Ming Chuong\u00a0Professor of Tissue Development and Regeneration at University of Southern California<\/p>\n What is 5G anyway?<\/a><\/strong><\/p>\n Internet Explorer? This is Spartan!<\/a><\/strong><\/p>\n How Dark Matter could mean disaster for earth<\/a><\/strong><\/p>\nDecision making in stem cell populations<\/h3>\n
![\"Collective-decision](\"http:\/\/businesstech.co.za\/news\/wp-content\/uploads\/2015\/04\/Quorum-Sensing.jpg\")
<\/a>Cast and count<\/h3>\n
Repair and regeneration<\/h3>\n
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